DirectMeds review
The short answer: DirectMeds charges $297 a month for compounded semaglutide injections, all in. Its FAQ says the starter dose ships as one 3-month supply billed in three payments.
By LongevityGLP1 desk, Publisher
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DirectMeds by the numbers
- From
- $297/mo · starting dose, month to month
- Prescribes
- Compounded semaglutide · Compounded tirzepatide
- Prescriber
- Doesn't say how the visit works
- Pharmacy
- Named on its site
- States
- 47 states
- Healthspan Score
- 36 out of 100
Our take on DirectMeds
DirectMeds prices compounded semaglutide injections at $297 a month and compounded tirzepatide at $399. Each price is all in: the medication, the physician evaluation, injection supplies, one- to two-day shipping and access to a licensed nurse, with no membership fee. Billing runs every 30 days rather than on calendar dates, and DirectMeds says it emails you five to seven days before each charge. If a physician doesn't approve the prescription, you get a full refund. The compounded semaglutide cost guide shows how that compares.
The detail that changes the first bill is in the FAQ. DirectMeds says the starter dose for injectable semaglutide is a single 3-month supply shipment, charged as three equal payments over three months. The pricing page says "cancel anytime," so ask before you order whether you can stop after the first payment. Its terms let you turn off auto-refill up to 48 hours before the next processing date, but medication that has shipped isn't refunded, and a returned medication carries a disposal fee.
There's a needle-free option too: semaglutide drops under the tongue at $249 a month. Drops are a compounded form, not an FDA-approved pill, and the GLP-1 pill lineup compares them with tablets and other swallow-it plans. Be careful with the product copy itself. The tirzepatide page lists features such as "FDA approved for long term weight loss" and a prefilled pen, which describe brand Zepbound, not a compounded vial from a pharmacy. The FDA letter shown on this page concerns how DirectMeds described its compounded GLP-1s against brand drugs.
DirectMeds names its chief medical officer, but the providers who prescribe work for third-party medical groups its terms don't name. A pharmacy page names ExperienceCare Pharmacy as its sterile compounding pharmacy for GLP-1s; one page calls its pharmacies 503A and another calls them 503B. Its pages also disagree on the states it can't serve: one says Mississippi and Louisiana, another Alabama and Mississippi, which leaves 47 states that neither page excludes. And the catalog includes BPC-157, a peptide FDA doesn't allow pharmacies to compound. If you're here for a GLP-1, keep your order to the GLP-1.
What DirectMeds costs
| Product | Real monthly cost | |
|---|---|---|
| Compounded semaglutideSublingual | $249/mo | $249/mo |
| Compounded semaglutideInjection | $297/mo | $297/mo |
| Compounded tirzepatideInjection | $399/mo | $399/mo |
Prices are taken from DirectMeds's own site and current as of this update. Real monthly cost folds in required fees and turns four-week billing into calendar months; that's our math.
Compounded semaglutide skips FDA approval: no one at the FDA judges whether it is safe, whether it works, or how well it was made before a pharmacy sends it out.
Want DirectMeds's current price for your dose?
Your monthly price is the same through our link.
What signing up looks like
Answer a short health qualifier
A few questions on your goals and health, then you choose a plan and pay for the first order.
A licensed provider reviews it
A provider from a third-party medical group reviews your intake. If you aren't approved, you get a full refund.
The pharmacy compounds it
A US compounding pharmacy prepares the prescription and ships it within a business day by one- to two-day delivery.
Refills every 30 days
Auto-refill bills every 30 days with an email beforehand. A licensed nurse checks in and helps with dose questions.
Who prescribes, and the pharmacy
Prescriptions come from licensed providers working for third-party medical groups that DirectMeds' terms don't name; its team page names a chief medical officer, Dr. Justin Hohl. DirectMeds doesn't say whether the visit is written or live. A pharmacy page names ExperienceCare Pharmacy as the sterile compounding pharmacy behind its GLP-1s, but its own pages call its pharmacies 503A in one place and 503B in another.
Where DirectMeds does well
- One all-in monthly price covers the drug, physician evaluation, supplies and fast shipping, with no membership fee.
- A licensed nurse is included with every GLP-1 plan for dose and side-effect questions.
- Names the pharmacy that makes its GLP-1s, ExperienceCare Pharmacy.
- Full refund if a physician doesn't approve your prescription.
- Needle-free semaglutide drops cost less a month than the injection.
What to check first
- The injectable semaglutide starter ships as a 3-month supply in three payments. Ask before you order.
- Tirzepatide copy calls it FDA approved and a prefilled pen; the compounded drug is neither. Read it as Zepbound's.
- Its pages disagree on which states it can't serve. Confirm your state with support before you pay.
- Also sells BPC-157, which FDA doesn't allow pharmacies to compound. Stick to the GLP-1 plan.
- Shipped medication isn't refunded. Turn off auto-refill at least 48 hours before the next charge.
It fits you if
You want compounded semaglutide or tirzepatide at one all-in price with nurse access and fast shipping, and you're fine committing to the first three months.
Look elsewhere if
You want to try a single month, need a clear answer on your state before paying, or would rather use a program that sells only drugs pharmacies may compound.
How DirectMeds scored
on the compounded semaglutide lineup
36out of 100
- Price1 of 35
$297 a month at the starting dose, month to month, fees folded in. Full points at $90 or less, none at $300 or more.
- Care10 of 25
- Not shown: Who prescribes
- Shown: A clinician reviews your intake
- Not shown: Labs and who pays
- Not shown: Follow-up schedule
- Shown: Dose changes at no new fee
- Pharmacy15 of 25
- Shown: Pharmacy named
- Not shown: Pharmacy state or type
- Shown: Brand or compounded is clear
- Not shown: No "FDA-approved" claim for a compounded drug
- Clarity10 of 15
- Shown: Price before the intake questions
- Shown: Cancel and refund terms
- Not shown: States served
Other lineups: Compounded tirzepatide 35 · GLP-1 pill program 52
Also on these lineups: Compounded oral semaglutide programs: 20 of 26
Three more providers to weigh
Shed
PartnerFrom $216/mo
Goldspan Health
From $248/mo
You + Me MD
Price after intake
FDA warning letter
The FDA sent a warning letter to the company behind DirectMeds on September 9, 2025. A letter is a public notice, not a ban, and it isn't part of the score. Read it and decide for yourself.
- Letter 716822, September 9, 2025 · Read the letter on the FDA's site
Questions about DirectMeds
- How much does DirectMeds cost a month?
- Compounded semaglutide injections are $297 a month and tirzepatide $399, all in, billed every 30 days. Semaglutide drops are $249 a month.
- Can I cancel DirectMeds after one month?
- Ask first. The FAQ says the injectable semaglutide starter ships as one 3-month supply charged in three payments. After that, you can turn off auto-refill up to 48 hours before the next charge.
- Which pharmacy does DirectMeds use?
- A DirectMeds pharmacy page names ExperienceCare Pharmacy, a sterile compounding pharmacy, as the maker of its GLP-1 medications.
- Does DirectMeds have an FDA letter?
- Yes. FDA wrote to DirectMeds in 2025 about how its site compared its compounded semaglutide and tirzepatide with brand-name drugs. The letter is linked on this page.
- Which states can't use DirectMeds?
- Its pages disagree. One lists Mississippi and Louisiana, another Alabama and Mississippi, which leaves 47 states neither excludes. Confirm with support before you order.
Read next
Picked for the same drugs and questions as this page.
- ResearchHow safe is compounded semaglutide? The risks FDA has documented
The known risks of semaglutide, the extra ones FDA has documented for compounded versions, and the checks you can run before your first dose.
- Drug guideSemaglutide: how it works and the products that contain it
Semaglutide copies GLP-1, a hormone your gut releases after eating. It raises insulin only when blood sugar is high, lowers glucagon, slows stomach emptying and reduces appetite through the brain. That is why it lowers blood sugar and body weight. It is sold as Ozempic and Rybelsus for diabetes and as Wegovy for weight.
- Side by sideWegovy or Mounjaro: start with which label fits you
Two different molecules from two different companies, approved for different people. Find your situation in the table and you'll know which label applies, and which drug is the fair comparison.
- ResearchDoes compounded semaglutide work as well as Wegovy?
The molecule has strong trial evidence behind it. A compounded vial borrows that evidence only if it holds the same molecule at the strength on its label.
Still weighing DirectMeds?
Where this review comes from
- DirectMeds pricing page
- DirectMeds compounded semaglutide product page
- DirectMeds compounded tirzepatide product page
- DirectMeds pharmacy and FAQ tabs on its patient portal product pages
- DirectMeds terms and conditions
- FDA warning letter to DirectMeds (MARCS-CMS 716822) (September 9, 2025)
Every fact here comes from DirectMeds's own public pages. Partner fees aren't one of the four checks.